Primary SMARCA4-deficient undifferentiated sarcomatoid tumor of the gastroesophageal junction
نویسندگان
چکیده
منابع مشابه
A rare tumor located in the anorectal junction: sarcomatoid carcinoma.
Sarcomatoid carcinoma is a very rare tumor. Though it has been more than a century since sarcomatoid carcinoma was first described by Wirchow, many unresolved points remain. Histogenesis and nomenclature are controversial. A proper management has not been defined. Patients suffering from this aggressive tumor have a very poor prognosis. However, in this paper a case with a disease-free survival...
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The tumor suppressor gene, SMARCA4 (or BRG1), which encodes the ATPase component of the chromatin remodeling complex SWI/SNF, is commonly inactivated by mutations and deletions in lung cancer cell lines. However, SMARCA4 alterations appear to be rare in lung primary tumors. Ultra-deep sequencing technologies provide a promising alternative to achieve a sensitivity superior to that of current se...
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Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated c...
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Adrenal sarcomatoid carcinomas are extremely rare tumors presenting with extensive locoregional spread at the time of diagnosis. Patients succumb to metastases within a couple of months. As a result, very few cases are reported in the literature until now. We present a case of a 62-year old female with non-functional sarcomatoid carcinoma of the right adrenal gland. There was no radiological ev...
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Introduction: Sarcomas account for 1% of all tumors originated in the head and neck regions in adults. They constitute a heterogeneous group of tumors of mesenchymal origin with multiple histological variants. The undifferentiated pleomorphic sarcoma (UPS) subtype is the most frequent variant with an incidence range of 2.7-38%. Materials and Methods: This retrospective...
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ژورنال
عنوان ژورنال: Human Pathology: Case Reports
سال: 2020
ISSN: 2214-3300
DOI: 10.1016/j.ehpc.2020.200432